Acne vulgaris is a bit more complex than just “blocked pores.” Current research highlights that changes in the skin's epidermal barrier play a significant role in how acne develops.¹ This barrier acts as the skin’s crucial internal support structure, essential for maintaining resilience and smooth function. A healthy barrier is vital; it protects the skin from microbes, locks in hydration, and limits external damage.² However, when this barrier becomes compromised, whether due to inflammation or environmental factors, the skin is left vulnerable. This leads to increased irritation, bacterial overgrowth, and the subsequent cascade of inflammatory breakouts that appear on the surface.⁴

While acne is often brushed off as "just a skin issue," its effects run deep. Even mild breakouts can leave behind more than just marks, leading to scarring and long-lasting emotional fallout. Acne can seriously undermine confidence, heighten anxiety, and even contribute to depression for some individuals.⁵⁻¹⁰ Getting the right support is crucial. This battle is about more than clearer skin, it’s about protecting your mental health and preventing permanent scars.¹¹

Understanding the root causes can help you feel more in control. Acne usually develops due to a mix of internal and external factors, including¹²⁻¹⁹:

Hormonal and Genetic Influences

• Increased oil (sebum) production

• High sensitivity to androgen hormones (e.g., testosterone)

• Family history of severe acne

• Hormonal conditions such as PCOS or insulin resistance

Lifestyle and Environmental Triggers

• Emotional stress (a big one for many people)

• Wearing masks or using heavy, occlusive skincare or makeup

• Certain medications or supplements (like lithium or iodides)

• Smoking or exposure to environmental toxins

Nutritional Factors

• Nutritional Deficiencies: Low levels of key nutrients, such as vitamin D or zinc.

• Highly Processed Diet: A diet high in sugar and low in overall nutrients.

• Dairy Consumption: For some individuals, excessive dairy intake can raise insulin-like growth factor (IGF-1), a chemical that may fuel breakouts in acne-prone skin.

Skin Barrier & Microbiome Issues

• A weakened skin barrier

• Changes in gut or skin microbes, including disruptions in the brain–gut–skin connection

• Bacterial overgrowth of certain strains of Cutibacterium acnes that increase inflammation

Because these factors are so diverse and interconnected, working with a qualified healthcare practitioner can help you identify your unique triggers and create a tailored plan for clearer, healthier skin.

A great first step is to talk to your doctor about available treatment options. If needed, they can refer you to a skin specialist who can help create a plan tailored to your needs. Conventional treatments often include one or more of the following.¹⁹ While these may not work for everyone, they can provide quick relief and support your wellbeing as you also take steps to address acne holistically.

• Topical retinoids – Often the first choice for mild to moderate acne
  Good to know: They can cause some dryness or irritation at first.
• Benzoyl peroxide – Another common first-line option
  Heads up: It can bleach towels and clothing, and may dry out the skin.
• Antibiotics (topical or oral) – Used for moderate to severe acne
  Consideration: Oral antibiotics can affect gut health.
• Isotretinoin – For severe acne or cases that don’t respond to other treatments
  Note: It’s powerful and effective but requires strict monitoring due to potential side effects.

Omega-3s, including EPA and DHA found in OmegaGenics High-Strength EPA & DHA, are natural inflammation-fighters, which is really important when it comes to calming acne from the inside out. Research shows they can work beautifully on their own or alongside conventional treatments.²⁵,²⁶ In one study, adding 2.4g of omega-3s to isotretinoin didn’t just help, it boosted results. This is what the research showed: