How does Estrovera assist with supporting mood symptoms, like irritability?

Low oestrogen levels can increase the activity of enzymes that accelerate the breakdown of feel-good brain chemicals, which can lead to mood changes. By gently stimulating oestrogen receptors, ERr 731™ limits the activity of these enzymes, which can support mood symptoms.7 References [7] Wei B, Yang ZD, Shi DF, Yao XJ, Wang MG. Inhibition of monoamine oxidase by stilbenes from Rheum palmatum. Iran J Pharm Res. 2016 Fall;15(4):885-892. PMID: 28243286

What are the stages of Menopause?

Menopause occurs in three stages: perimenopause, menopause and post-menopause. For many women, the menopause transition can last 8 to 10 years and may affect sleep, mood, energy levels, joint comfort and overall wellbeing.1 The timing of menopause varies between individuals and may be influenced by factors such as genetics, lifestyle and certain medical procedures, including hysterectomy.1References: Jean Hailes For Women's Health. Menopause Information Sheet [Internet]. [updated 4/03/2020; cited 23/07/2020]. Available from: https://www.jeanhailes.org.au/health-a-z/menopause/about-menopause#

What is Perimenopause and what changes can I expect?

Perimenopause is the stage leading up to menopause, when hormone levels begin to fluctuate, and menopause symptoms may first appear. It typically occurs during a woman's 40s, although timing can vary.1 During perimenopause, women may experience irregular periods, hot flushes, sleep disturbances, mood changes, changes in libido and changes in sexual function.1,3 Perimenopause continues until a woman's final menstrual period.3References: 1Jean Hailes For Women's Health. Menopause Information Sheet [Internet]. [updated 4/03/2020; cited 23/07/2020]. Available from: https://www.jeanhailes.org.au/health-a-z/menopause/about-menopause# 2Australasian Menopause Society. The Perimenopause or Menopausal Transition Information Sheet [Internet]. [updated October 2017; cited 27/08/2020]. Available from: https://www.menopause.org.au/hp/information-sheets/1057-perimenopause

What is Menopause and what can I expect?

Menopause is defined as the point when a woman has not had a menstrual period for 12 consecutive months. In Australia, menopause typically occurs between 45 and 55 years of age, with the average age around 51 years.1 During menopause, ovulation ceases and oestrogen levels decline.1 Common menopause symptoms include hot flushes, sleep disturbances, fatigue, irritability, vaginal dryness, and mild muscle or joint discomfort.1,2 Every woman's experience is different, with some experiencing few or no symptoms while others experience symptoms that significantly impact daily life.1 References: 1Jean Hailes For Women's Health. Menopause Information Sheet [Internet]. [updated 4/03/2020; cited 23/07/2020]. Available from: https://www.jeanhailes.org.au/health-a-z/menopause/about-menopause# 2Zhou Y, Zheng Y, Li C, Hu J, Zhou Y, Geng L & Tao M. Association of body composition with menopausal symptoms in (peri) menopausal women. 2018; 21 (2): 179-183.

What is Post-Menopause?

Post-menopause is the stage after menopause, beginning once a woman has gone 12 months without a menstrual period.1 Often described as a "new equilibrium", post-menopause follows the menopause transition and can continue for the remainder of a woman's life.3 During post-menopause, some menopause symptoms may improve as hormone levels stabilise, although certain symptoms can persist for some women.3References: 1Jean Hailes For Women's Health. Menopause Information Sheet [Internet]. [updated 4/03/2020; cited 23/07/2020]. Available from: https://www.jeanhailes.org.au/health-a-z/menopause/about-menopause# 3Australasian Menopause Society. The Perimenopause or Menopausal Transition Information Sheet [Internet]. [updated October 2017; cited 27/08/2020]. Available from: https://www.menopause.org.au/hp/information-sheets/1057-perimenopause

Do all women experience symptoms during menopause?

No. Not all women experience the same menopausal symptoms. Around 20% of women don't experience any symptoms of menopause, 60% experience mild to moderate symptoms, and 20% experience symptoms that interfere with daily life.11Jean Hailes For Women's Health. Menopause Information Sheet [Internet]. [updated 4/03/2020; cited 23/07/2020]. Available from: https://www.jeanhailes.org.au/health-a-z/menopause/about-menopause#

Metagenics Estrovera®: 1 Daily Tablet, 8 Menopause Symptoms Relieved!

Name: Estrovera 30 Tablets
Brand: Metagenics
SKU: ET30
Price: 35.95 AUD
Availability: InStock

Plant-derived alternative for Menopause relief & Perimenopause support.

1 9

Plant-derived alternative for Menopause relief & Perimenopause support.

Benefits

Try this best seller on our Money Back Guarantee*
Formulated with clinically proven proprietary extract ERr 731®.
Relieves hot flushes & irritability.
Reduces restless sleep & fatigue.
Supports healthy libido.
Decreases vaginal dryness.
Reduces muscle aches & mild joint pain.

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Hot Flush Relief from 4 weeks

Clinically Proven Ingredient

One Daily Dose

Vegan

Description

Metagenics Estrovera® is a revolutionary option for women seeking a solution to the challenges of menopause. With just one mini tablet per day, you can find relief from 8 common menopause symptoms and support through perimenopause, helping you feel like yourself again.

Formulated with a clinically proven proprietary extract, known as ERr 731®, a plant-derived alternative for menopause.

Track your menopause symptoms, monitor progress and identify trends with our Menopause Guide.

Benefits of Estrovera®.

Up to 80% reduction in menopausal symptoms*:

Relieves hot flushes from 4 weeks^
Relieves irritability fatigue
Reduce disturbed and restless sleep
Decreases vaginal dryness
Supports healthy libido
Reduces muscle aches mild joint pain

How does Estrovera® help with Perimenopause?

Estrovera® helps perimenopausal women maintain general health and wellbeing, ensuring they feel their best during this transitional phase, as well as:

Supports emotional wellbeing
Soothe & calms nerves
Maintains healthy libido sexual function

Recommended Use:

For optimal results, we recommend taking Estrovera® for at least 90 days.

Take control of your menopause journey with Estrovera®. Feel confident, supported, and ready to embrace this new chapter of your life.

^{*Hasper et al. Long-term efficacy and safety of the special extract ERr 731® Rheum rhaponticum. 2009.}
^{^Survey conducted online by Metagenics September 2020 with 75 women currently taking Estrovera.}

Directions & Warnings

Directions

Adult Women only: Take 1 mini tablet daily with food, or as directed by your healthcare professional.

Storage

Store below 30°C.

Warnings

This product contains Rheum rhaponticum and this product may have laxative effect.
If symptoms persist consult your healthcare professional.
Do not use if cap and/or seals are missing or broken.

Delivery Options

Metro Express, 1-3 days $13.95

Non-Metro Express, 2-5 days $13.95

Read full shipping policy

Day 1
Start your ritual of one mini tablet daily
Day 30
Experience fewer and less severe hot flushes [1]
Day 90
Relief from hot flushes [2]

Key Ingredients

ERr 731®

ERr 731®, also known as Siberian rhubarb, is a medicinal plant used widely across Europe to support perimenopausal women & relieve menopause symptoms for more than 20 years[5]. ERr 731® has been shown in clinical trials to significantly improve hot flushes, nervous tension and low sex drive has helped countless women achieve fantastic results in as little as four weeks^, with 80% reduction in menopause symptoms at 12 weeks*.

Full active ingredients

Each tablet contains

Rheum rhaponticum, dry root extract

4 mg

From dry root (ERr 731®)

84 mg

Free from

Free from Animal Products Free from Corn

Free from Dairy Protein

Free from Lactose

Free from Eggs

Free from Gluten

Free from Wheat

Free from Nuts

Free from Yeast

Free from Soy Protein Free from Artificial Colours Free from Artificial Flavours Free from Artificial Preservatives Free from Starches

Excipients

croscarmellose sodium, ethylcellulose, hyprolose, hypromellose, medium chain triglycerides, microcrystalline cellulose, oleic acid, purified water, silicon dioxide, sodium alginate, stearic acid, strong ammonia solution.

Free from Animal Products
Free from Corn
Free from Dairy Protein
Free from Lactose
Free from Eggs
Free from Gluten
Free from Wheat
Free from Nuts
Free from Yeast
Free from Soy Protein
Free from Artificial Colours
Free from Artificial Flavours
Free from Artificial Preservatives
Free from Starches

Free from Animal Products
Free from Corn
Free from Dairy Protein
Free from Lactose
Free from Eggs
Free from Gluten
Free from Wheat
Free from Nuts
Free from Yeast
Free from Soy Protein
Free from Artificial Colours
Free from Artificial Flavours
Free from Artificial Preservatives
Free from Starches

How long does it take to see results from using Estrovera®?

Within 4 weeks, ERr 731™ can improve 11 perimenopause symptoms by 14% to 28%, including, poor sleep, irritability, fatigue, sore joints and vaginal dryness.1 After 12 weeks of ERr 731™ use, perimenopausal symptoms were shown to improve by 45% to 78%.1,2

References
[1] Shah J, Chandanani S, Reddy J, et al. Evaluation of the efficacy and safety of Rheum rhaponticum Root extract (ERr 731) for menopausal symptoms in perimenopausal Indian women: an interim analysis. J Mid-life Heal. 2021;12(2):108-115. doi:10.4103/jmh.jmh_86_21

[2] Hasper I, Ventskovskiy BM, Rettenberger R, Heger PW, Riley DS, Kaszkin-Bettag M. Long-term efficacy and safety of the special extract ERr 731 of Rheum rhaponticum in perimenopausal women with menopausal symptoms. Menopause. 2009 Jan-Feb;16(1):117-31. doi: 10.1097/GME.0b013e3181806446

Is Estrovera® hormone-free?

Yes, Estrovera® is a hormone-free plant extract from the root of Rheum rhaponticum (Siberian rhubarb). This special extract, called ERr 731® contains concentrated plant compounds, which act on specific oestrogen receptors throughout the body which helps to relieve menopausal symptoms.  It is found safe in both animal studies and clinical trials.3-5 

References
[3] Heger M, Ventskovskiy BM, Borzenko I, Kneis KC, Rettenberger R, Kaszkin-Bettag M, et al. Efficacy and safety of a special extract of Rheum rhaponticum (ERr 731) in perimenopausal women with climacteric complaints. Menopause. 2006;13(5):744-759. doi:10.1097/01.gme.0000240632.08182.e4

[4] Wilson M, Konda V, Heidt K, Rathinasabapathy T, Desai A, Komarnytsky S. Rheum rhaponticum Root Extract Improves Vasomotor Menopausal Symptoms and Estrogen-Regulated Targets in Ovariectomized Rat Model. Int J Mol Sci. 2021;22(3):1032. doi:10.3390/ijms22031032

[5] Dubey VP, Sureja VP, Kheni DB. Efficacy evaluation of standardized Rheum rhaponticum root extract (ERr 731®) on symptoms of menopause: A systematic review and meta-analysis study. J Biomed Res. 2024;38(3):278-286. doi:10.7555/jbr.37.20230219

How does Estrovera® work in the body?

ERr 731™ gently mimics the effects of oestrogen on a specific receptor found throughout the body, called oestrogen receptor beta. This helps to balance the effects of fluctuating oestrogen levels during perimenopause without altering the body's natural hormone levels.3-6

References
[3] Heger M, Ventskovskiy BM, Borzenko I, Kneis KC, Rettenberger R, Kaszkin-Bettag M, et al. Efficacy and safety of a special extract of Rheum rhaponticum (ERr 731) in perimenopausal women with climacteric complaints. Menopause. 2006;13(5):744-759. doi:10.1097/01.gme.0000240632.08182.e4

[4] Wilson M, Konda V, Heidt K, Rathinasabapathy T, Desai A, Komarnytsky S. Rheum rhaponticum Root Extract Improves Vasomotor Menopausal Symptoms and Estrogen-Regulated Targets in Ovariectomized Rat Model. Int J Mol Sci. 2021;22(3):1032. doi:10.3390/ijms22031032

[5] Dubey VP, Sureja VP, Kheni DB. Efficacy evaluation of standardized Rheum rhaponticum root extract (ERr 731®) on symptoms of menopause: A systematic review and meta-analysis study. J Biomed Res. 2024;38(3):278-286. doi:10.7555/jbr.37.20230219

[6] Kaszkin-Bettag M. Beck S, Richardson A, Heger PW, Beer AM. Efficacy of the special extract ERr 731 from rhapontic rhubarb for menopausal complaints: a 6-month open observational study. Altern Ther Health Med. 2008 Nov-Dec;14(6):32-38. PMID: 190439363

What happens if I stop taking Estrovera®?

Stopping Estrovera® may result in symptoms returning although women may safely resume taking. However, symptoms may not reappear if a woman has completed her menopausal transition.

What if Estrovera® does not relieve my menopausal symptoms?

Whilst Estrovera® is shown to help most women, around 10% report no improvement. This may be due to other existing health concerns, or the effects of diet, exercise, lifestyle or stress overriding the soothing benefits of Estrovera®. For more personalised insights, please see your healthcare professional to assess if Estrovera® is right for you.

Can I take Estrovera® if I am on the oral contraceptive pill (OCP), hormone replacement therapy (HRT) or menopausal hormone therapy (MHT)?

To ensure Estrovera® is right for you, please discuss with your healthcare professional and/or dispensing pharmacist who can advise on any possible interactions with your medications. 

Woman in her mid-forties tending to houseplants

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Overall rating: 4.8333335 / 5 from 102 reviews.

AI Generated Review Summary

The fabric of Estrovera tablets is designed for ease of use with a mini tablet size, providing relief from hot flushes and night sweats. Users report improvements in mood and sleep quality, with some experiencing reduced irritability and fatigue. The product is formulated with a plant-derived extract to support women during menopause and perimenopause.

Summary topics

Symptom Relief Results (8%): It was noted by customers that they are happy with the results of taking Metagenics Estrovera for menopause symptoms.
Overall Product Effectiveness (8%): Customers raved about Estrovera for its noticeable improvement in mood and menopause symptoms.
Mood and Sleep Improvement (9%): Customers keep praising Estrovera for making a huge difference in their mood and sleep.
Night Sweat Relief (8%): It was noted by customers that this product has helped with night sweats and menopause symptoms.
Hot Flush Relief (19%): Many customers brought up that they have experienced relief from hot flushes after taking Estrovera tablets.

Review topics: ["results","quality","improvement","flushes","relief","symptoms","energy","flashes","body","sleep","estrovera","difference","mood","night sweats","night","supplement","tablets","work"].

Review highlights

"The flow on effect of that is better sleep, so mood and energy the following day are better." — Jess H.
"This is a great product, it works so well to keep hot flushes away." — Jules
"This has eased my menopause symptoms, no night sweats , no hot flushes." — Julie M.

Reviews

Reduced hot flushes in the first week

"I'm 68 and have been having 6-8 hot flushes every night for 10 years. I prefer natural products, so gave Estrovera a try, and it actually worked. After a week on the tablets, my hot flushes have reduced to 1 / night, and my sleep is much better. I haven't experienced any mood improvement, yet. But I'm still hopeful."

— Kym M. (5/5)

Reduced Perimenopause Symptoms

"I have been using Estrovera for about 2 months now and I can say my perimenopause symptoms have reduced especially my hot flushes. I haven't had a hot flush during the day for some time and I occasionally get a night time flush. My improved sleep has helped with my fatigue which helps with my daily activities. I would highly recommend Estrovera for anyone experiencing perimenopause and menopause symptoms."

— Nerissa P. (5/5)

Metagenics Estrovera

"I've been taking Metagenics Estrovera for my menopause symptoms and I'm so pleased with the results. I am on my second bottle of 90 tablets and have noticed a real improvement in my hot flashes during the day, sleep, and overall emotional well being. I've felt more balanced and love that it's a non-hormonal option. If I forget to take it I feel the difference immediately. I can recommend Estrovera to other woman looking for support during menopause."

— Sumarie S. (5/5)

A Game Changer!

"After just one week, my hot flushes have gone, night sweats disappeared and mood noticeably improved. This product has been a game changer for me."

— Melissa P. (5/5)

"good product"

— Ana (5/5)

"amazing product thanks"

— Ana (5/5)

Has reduced hot flashes and

"Has reduced hot flashes and other symptoms helped with sleep"

— Kirstin H. (5/5)

"Caused excessive sweating not right for me"

— Gillian (1/5)

This is just perfect for

"This is just perfect for me at my age. So helpful with all the symptoms I was experiencing."

— Judith W. (5/5)

It actually works!!!

"Amazing! After taking these for nearly a month now, have gone from countless hot flashes during the day and night sweats with broken sleep, to counting on one hand the amount I have had. It took just over a week to notice significant changes. This product has worked for me."

— Amanda B. (5/5)

Q&A

References

**Money Back Offer T&Cs apply. Subject to claim dates and promotional period.
*Hasper et al. Long-term efficacy and safety of the special extract ERr 731® Rheum rhaponticum. 2009.
^Survey conducted online by Metagenics September 2020 with 75 women currently taking Estrovera.
1. Wober J, Möller F, Richter T, Unger C, Weigt C, Jandausch A, et al. Activation of estrogen receptor-beta by a special extract of Rheum rhaponticum (ERr 731), its aglycones and structurally related compounds. J Steroid Biochem Mol Biol. 2007 Nov-Dec;107(3-5):191-201. doi: 10.1016/j.jsbmb.2007.04.00
2. Shah J, Chandanani S, Reddy J, et al. Evaluation of the efficacy and safety of Rheum rhaponticum root extract (ERR 731) for menopausal symptoms in perimenopausal Indian Women: An Interim Analysis. J Midlife Health. 2021;12(2):108-115. doi:10.4103/jmh.jmh_86_21
3. Heger M, Ventskovskiy BM, Borzenko I, Kneis KC, Rettenberger R, Kaszkin-Bettag M, Heger P. Efficacy and safety of a special extract of Rheum rhaponticum (ERr 731) in perimenopausal women with climacteric complaints: a 12-week randomized, double-blind, placebo-controlled trial. The Journal of The North American Menopause Society. 2006; 13(5): 744-59.
4. Kaszkin‐Bettag M, Ventskovskiy BM,Solskyy S, Beck S, Hasper I,Kravchenko A, Rettenberger R,Richardson A, Heger P.Confirmation of the efficacy of ERr731 in perimenopausal women with menopausal symptoms. AlternativeTherapies in Health and Medicine. 2009; 15 (1): 24–34.
5. Grundemann C. Hertrampf A. Sauer B. Garcia-Kaufer M. Zehl M. Huber R. Influence of Rheum rhaponticum, Cimicifuga racemosa and Trifolium pratense extracts on breast cancer cell proliferation. ZPT- Zeitschrift fur Phytotherapie. 2015; 36: 157-163.