Your gut does far more than digest food; it helps run the show.
Inside your digestive tract live 500 to 1,000 different types of microbes, collectively known as your microbiome. Remarkably, they number about the same as your human cells. Together, they influence everything from digestion and immune function to energy, mood, and overall well-being. As research evolves, one thing is clear: supporting your microbiome is a daily investment in whole-body health. And probiotics can be powerful tools, especially when specific, clinically studied strains are combined with a purpose.
The right combinations have been shown to help maintain healthy gut bacteria, ease digestive discomfort, and support consistent, everyday balance.In this article, we explore two evidence-based probiotic combinations featuring researched strains, including NCFM®, Bi-07®, LGG®, and CLEPIUS™ Lpla33™, selected for their ability to survive digestion and actively support your gut environment. You’ll find these strains in Ultra Flora Daily Balance Dairy Free and UltraFlora Probiotic + Multivitamin; thoughtfully formulated to support microbial balance and whole-body wellbeing, every day.
Your Gut is a Garden & Probiotics Help Improve It's Overall Health
Probiotics aren’t just a wellness trend, they’re strategic support for one of the most important systems in your body. These live, beneficial bacteria help maintain the balance of your gut microbiome. And that balance is everything. When good bacteria are strong and diverse, digestion runs smoothly, your immune system stays supported, and your body operates efficiently. When they’re depleted, the whole system can feel off.
Think of your gut like a rainforest. When it’s rich and diverse, it’s resilient. Fibre feeds the beneficial bacteria, and probiotics help reinforce and strengthen the ecosystem so it can thrive. But if diversity drops, the environment becomes fragile. Supporting your gut bacteria means protecting the foundation of your health. And the right, well-researched probiotic combinations can help you do exactly that, strengthening your inner ecosystem so it works for you, every single day.

Probiotic Combination 1: NCFM® + Bi-07® + LGG®
This clinically researched trio is designed to survive digestion, work together, and deliver measurable results. Lactobacillus acidophilus NCFM® is backed by 40+ years of research and over 30 clinical trials. It survives stomach acid, reaches the intestines alive, and helps reduce bloating and digestive discomfort.²⁻⁶ It also supports immune function and helps beneficial bacteria thrive on dietary fibre.
Bifidobacterium lactis Bi-07® complements NCFM® by breaking down a wide range of fibres and producing beneficial compounds that nourish your gut environment.⁷ Studied since 1997, it’s been shown to support immune defence and regular bowel movements. In one study, women experienced relief from constipation within 30 days.⁸ Lastly, Lactobacillus rhamnosus LGG® is one of the most documented probiotic strains globally, helping stabilise and protect the gut ecosystem, reinforcing the environment your beneficial bacteria need to flourish.⁹
Together, these three strains work synergistically to maintain healthy gut bacteria, support digestive comfort, and strengthen microbial resilience. You’ll find this evidence-based combination in UltraFlora Daily Balance Dairy Free, a streamlined daily probiotic focused purely on maintaining gut balance and digestive wellbeing.
Probiotic Combination 2: LGG® + CLEPIUS™ Lpla33™
This pairing brings together the proven stability of LGG® with the clinically studied benefits of Lactiplantibacillus plantarum CLEPIUS™ Lpla33™, a strain shown to support both digestive symptoms and mood. LGG®, researched since 1989, helps stabilise the gut by supporting “keystone” species, the foundational bacteria that hold your inner ecosystem together. Its strength lies in protecting and reinforcing microbial balance.⁹ These wide-ranging benefits of LGG® appear to help at a high dose of 10 to 20 billion colony-forming units daily, provided in a single capsule of Ultra Flora LGG Forte.
Beyond LGG® alone, CLEPIUS™ Lpla33™ delivers targeted digestive support. In clinical research, adults experienced noticeable reductions in bloating within four weeks. After eight weeks, abdominal pain and bloating symptoms improved by 40% compared to 20% with placebo.¹⁰ This combination supports digestive comfort while also acknowledging what the science now confirms: when your gut feels better, you often feel better overall.
You’ll find LGG® and Lactobacillus plantarum CLEPIUS™ Lpla33™ in UltraFlora Probiotic + Multivitamin, a convenient 2-in-1 formula that pairs clinically researched probiotics with a comprehensive multivitamin. It supports gut balance while helping fill nutritional gaps, boost energy, and streamline your daily routine.
Bringing Balance Back to Your Gut
Just like a rainforest, your gut relies on its beneficial species. When balance disrupts, targeted probiotics can restore harmony and keep your inner ecosystem strong. To support your gut health, click here to explore our digestive health range. You can also talk to a healthcare practitioner to find the best option for you.
References
- Davenport ER, Sanders JG, Song SJ, Amato KR, Clark AG, Knight R. The human microbiome in evolution. BMC Biol. 2017;15(1):127. doi:10.1186/s12915-017-0454-7\
- National Institutes of Health, Office of Dietary Supplements. Probiotics: Health Professional Fact Sheet. Updated November 3, 2023. Accessed May 2, 2025.
- Andersen JM, Barrangou R, Hachem MA, et al. Transcriptional analysis of prebiotic uptake and catabolism by Lactobacillus acidophilus NCFM. PLoS One. 2012;7(9):e44409.
- Mäkeläinen H, Saarinen M, Stowell J, et al. Xylo-oligosaccharides and lactitol promote the growth of Bifidobacterium lactis and Lactobacillus species in pure cultures. Benef Microbes. 2010 Jun;1(2):139-48.
- Ringel Y, Ringel-Kulka T, Palsson OS, et al. Probiotic bacteria Lactobacillus acidophilus NCFM and Bifidobacterium lactis Bi-07 versus placebo for the symptoms of bloating in patients with functional bowel disorders: a double-blind study. J Clin Gastroenterol. 2011Jul;45(6):518-25.
- Ringel-Kulka T, Goldsmith JR, Carroll IM, et al. Lactobacillus acidophilus NCFM affects colonic mucosal opioid receptor expression in patients with functional abdominal pain - a randomised clinical study. Aliment Pharmacol Ther. 2014 Jul;40(2):2007.
- Maneerat S, Lehtinen MJ, Childs CE, et al. Consumption of Bifidobacterium lactis Bi-07 by healthy elderly adults enhances phagocytic activity of monocytes and granulocytes. J Nutr Sci. 2014;2:e44. doi:10.1017/jns.2013.31
- Favretto DC, Pontin B, Moreira TR. Effect of the consumption of a cheese enriched with probiotic organisms (Bifidobacterium lactis bi-07) in improving symptoms of constipation. Arq Gastroenterol. 2013;50(3):196-201. doi:10.1590/S0004-28032013000200035
- Capurso L. Thirty Years of Lactobacillus rhamnosus GG: A Review. J Clin Gastroenterol. 2019;53 Suppl 1:S1-S41. doi:10.1097/MCG.0000000000001170
- Martoni CJ, Srivastava S, Damholt A, Leyer GJ. Efficacy and dose response of Lactiplantibacillus plantarum in diarrhea-predominant irritable bowel syndrome. World J Gastroenterol. 2023;29(28):4451-4465. doi:10.3748/wjg.v29.i28.4451